Fig. 3. Synergy distribution in different combination MoA group categories.

Combination-cell line pairs were categorized into MoA groups based on the molecular targets of the compounds with the lowest binding affinity value. Combination MoA groups were sorted based on the calculated mean synergy. We observed a generally higher synergy in the case of DDRi:DDRi combinations, compared to pairs where DDR inhibition was combined with compounds acting beyond DDR.