Table 1.

Thresholds of synergy categories determined by K-means clustering

	Non-synergistic	Moderately synergistic	Strongly synergistic
Interval of in silico synergy scores	Bliss score <0.24	0.24 < Bliss score <0.67	Bliss score >0.67
Number of combination-cell line pairs	47583	5212	13437
Percentage of combination-cell line pairs	71.84%	7.86%	20.8%

Most of the combination-cell line pairs were not synergistic based on the low in silico Bliss values, while the majority of the remaining combinations (20.8% of all) were considered to be strongly synergistic.