TABLE 1.
Antiviral activity of MRL-1237, guanidine hydrochloride, HBB, and enviroxime against enteroviruses
| Virus strain | Antiviral activity (μM)a
|
|||||||
|---|---|---|---|---|---|---|---|---|
| MRL-1237
|
Guanidine hydrochloride
|
HBB
|
Enviroxime
|
|||||
| EC50 | SI | EC50 | SI | EC50 | SI | EC50 | SI | |
| Mahoney | 11 | 51 | 720 | 24 | >200 | <1.9 | 0.30 | 170 |
| Sabin 1 | 9.5 | 59 | 340 | 50 | >200 | <1.9 | 0.31 | 160 |
| Sabin 2 | 2.9 | 190 | 320 | 53 | 26 | 15 | 0.11 | 450 |
| Sabin 3 | 7.0 | 80 | 390 | 44 | 170 | 2.2 | 0.17 | 290 |
| CB3 Nancy | 0.58 | 970 | 2,200 | 7.7 | 70 | 5.4 | 0.26 | 190 |
| CB4 JVB | 0.55 | 1,000 | 2,100 | 8.1 | 66 | 5.8 | 0.14 | 360 |
a
CC50 values (μM) were as follows: MRL-1237, 560; guanidine hydrochloride, 17,000; HBB, 380; and enviroxime, 50. SI, selective index, measured as the ratio CC50:EC50.