. 2024 Jun 21;14:14338. doi: 10.1038/s41598-024-65310-y

Table 3.

Details of heterogeneity and pleiotropy check in the MR analysis.

Exposure	Outcome date source	Heterogeneity				Horizontal pleiotropy
		IVW		MR egger		Horizontal pleiotropy
		Q	P	Q	P	Q	P
Mets	PRACTICAL	208.774	0.002	208.565	0.0019	0.000948	0.696
Mets	FinnGen	321.798	1.85E−09	321.708	1.42E−09	− 0.000911	0.821
TG	PRACTICAL	51.122	0.112	46.906	0.180	0.000549	0.068
TG	FinnGen	85.278	0.003	85.238	0.002	0.000659	0.877
HDL	PRACTICAL	97.211	0.021	96.411	0.02	0.001867	0.449
HDL	FinnGen	172.778	1.95E−08	170.861	2.24E−08	− 0.00446	0.343
DBP	PRACTICAL	684.105	4.66E−15	683.265	4.28E−15	0.001071	0.474
DBP	FinnGen	713.485	4.48E−17	712.969	3.82E−17	0.001347	0.58
SBP	PRACTICAL	667.819	1.39E−13	667.396	1.19E−13	− 0.000778	0.606
SBP	FinnGen	652.694	7.04E−12	652.509	5.84E−12	0.000832	0.729
FBG	PRACTICAL	27.246	0.293	27.234	0.246	0.000443	0.921
FBG	FinnGen	46.672	0.027	42.411	0.052	0.01249	0.098
WC	PRACTICAL	41.249	0.183	40.641	0.169	0.003084	0.487
WC	FinnGen	77.467	0.001	77.08	0.001	− 0.003679	0.649

MetS metabolic syndrome, WC waist circumference, SBP systolic blood pressure, DBP diastolic blood pressure, TG triglycerides, HDL high density lipoprotein, FBG fasting blood glucose.