Table 3.

Meta-analysis results of prediction error (log₁₀ POD ratio) and correlation statistics for six-cell-type dataset consisting of 15 chemicals. The correlation statistics are analyzed between in vitro PODs and in vivo PODs.

	in vivo vs. ToxCast PODs				in vivo vs. Six-cell-type PODs
	Pooled log10 POD ratio (CI) [PI]	I2 (%)	tau	ρ	Pooled log10 POD ratio (CI) [PI]	I2 (%)	tau	ρ
Reg	−1.30 (−1.96, −0.64)	84.60	1.43	−0.31	−0.90 (−1.61, −0.19)	86.80	1.56	0.13
PODA	[−3.74, 1.14]				[−3.56, 1.76]
Reg	−0.47 (−1.08, 0.14)	82.20	1.31	−0.26	−0.07 (−0.67, 0.53)	81.40	1.27	0.11
PODH	[−2.71, 1.77]				[−2.25, 2.11]
BMA	−1.33 (−2.12, −0.54)	97.60	1.81	−0.04	−0.94 (−1.73, −0.14)	97.60	1.82	0.53
BMDA	[−4.42, 1.75]				[−4.03, 2.15]
BMA	−0.57 (−1.35, 0.20)	95.50	1.78	0.08	−0.18 (−0.93, 0.58)	95.20	1.72	0.41
BMDH	[−3.58, 2.43]				[−3.10, 2.75]

Abbreviations: Reg POD_A = original regulatory POD in animal dose units; Reg POD_H = original regulatory POD converted to human equivalent dose units; BMA BMD_A = Bayesian model averaging-based benchmark dose in animal dose units; BMA BMD_H = Bayesian model averaging-based benchmark dose converted to human equivalent dose units; log₁₀ POD ratio = log₁₀(in vitro POD/in vivo POD); CI: 90% confidence interval on the average log₁₀ POD ratio; PI: 90% prediction interval for a new random chemical; I² = statistic describing the percentage of variation across chemicals that is due to inter-chemical variability rather than uncertainty in individual PODs; tau = estimated random effects standard deviation for the inter-chemical variability in log₁₀ POD ratio; ρ = Spearman correlation coefficient of log₁₀(in vitro POD) vs. log₁₀(in vivo POD).