Table 4.
Meta-analysis results of prediction error (log10 POD ratio) and correlation statistics for 41-chemical dataset. The correlation statistics are analyzed between in vitro PODs and in vivo PODs.
| in vivo vs. ToxCast PODs | in vivo vs. cardiomyocyte PODs | |||||||
|---|---|---|---|---|---|---|---|---|
|
|
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| Pooled log10 POD ratio (CI) [PI] | I2 (%) | tau | ρ | Pooled log10 POD ratio (CI) [PI] | I2 (%) | tau | ρ | |
| Reg | −1.61 (−2.02, −1.19) | 85.70 | 1.49 | −0.07 | −0.49 (−0.88, −0.10) | 84.20 | 1.40 | 0.12 |
| PODA | [−4.09, 0.88] | 0 | [−2.83, 1.85] | |||||
| Reg | −0.75 (−1.15, −0.35) | 85.00 | 1.45 | −0.07 | 0.37 (−0.03, 0.77) | 84.70 | 1.43 | 0.1 |
| PODH | [−3.16, 1.66] | 0 | [−2.02, 2.76] | |||||
| BMA | −1.73 (−2.20, −1.26) | 98.9 | 1.78 | 0.17 | −0.63 (−1.08, −0.18) | 98.80 | 1.69 | 0.08 |
| BMDA | [−4.70, 1.23] | 0 | [−3.44, 2.18] | |||||
| BMA | −0.92 (−1.38, −0.46) | 97.3 | 1.73 | 0 | 0.18 (−0.27, 0.63) | 97.20 | 1.68 | 0.11 |
| BMDH | [−3.80, 1.96] | 0 | [−2.62, 2.97] | |||||
Abbreviations: Reg PODA = original regulatory POD in animal dose units; Reg PODH = original regulatory POD converted to human equivalent dose units; BMA BMDA = Bayesian model averaging-based benchmark dose in animal dose units; BMA BMDH = Bayesian model averaging-based benchmark dose converted to human equivalent dose units; log10 POD ratio = log10(in vitro POD/in vivo POD); CI: 90% confidence interval on the average log10 POD ratio; PI: 90% prediction interval for a new random chemical; I2 = statistic describing the percentage of variation across chemicals that is due to inter-chemical variability rather than uncertainty in individual PODs; tau = estimated random effects standard deviation for the inter-chemical variability in log10 POD ratio; ρ = Spearman correlation coefficient of log10(in vitro POD) vs. log10(in vivo POD).