Fig. 7.

The TRAIL/venetoclax combination reduces tumor burden and prolongs survival in a PDX mouse model of AML. a The schematic depiction of experiments about the PDX mouse model constructed with bone marrow leukemic cells from AML#3 patient with NPM1 mutant. b The weights of all the mice were recorded during the experiment. c Quantification of hCD45.⁺ leukemic cells from PDX mice by FCM (n = 3). d Wright’s staining of bone marrow immature cells (Scale bar: 100 μm). The red arrow indicates the immature cells. e Images of spleen appearance. f H&E staining of liver (f, upper) and spleen (f, lower) from one representative mouse in each group (Scale bar: 50 μm). g IHC staining of cleaved CASP 8 (g, upper) and cleaved CASP 3 (g, lower) expression in the spleen. h Kaplan–Meier survival curve of mice in each group. The mice treated with an equal amount of vehicle were used as controls. The data are representative of at least three independent experiments. BM, bone marrow. * p < 0.05