Fig. 2.

Deletion of c-Met from immune cells attenuates lung injury following BLM administration. WT and cKO mice administered intratracheally with BLM were followed for (A) weight change and (B) survival. n = 5–24 mice per group. (C) Representative images of H&E-stained lung sections from vehicle-administered mice, and on days 5 and 7 after BLM injection and (D) respective scoring. Original magnification × 20, scale bar 50 µm. LDH activity in the (E) dissociated tissue and (F) BAL supernatant at 7 days after BLM injection. (G) Gene expression of repair-associated molecules (Tgf-β1, Igf-1, Ctgf) in the lung at 7 days after BLM injection. n = 12–14 per group. Data are expressed as mean ± SEM and were analyzed by Student’s two-tailed t test (A, D, G), log-rank test (B) or with one-way ANOVA with Tukey’s multiple comparisons test (E, F). *p < 0.05, **p < 0.01. Similar results were obtained in three independent experiments