Table 1.
Disease characteristics.
| Case | Age (y) at SLE diagnosis | SLE manifestations | Treatment during disease course | Previous pregnancies | Age (y) and SLEDAI at BEL start | Treatment at start of BEL | Post-BEL outcome | Concomitant post-BEL treatment |
|---|---|---|---|---|---|---|---|---|
| 1 | 9 | Fever, oral ulcers, subacute cutaneous lupus, alopecia, asthenia, anaemia, leukopenia, polyarticular arthritis, low complements, dsDNA | PD, HCQ, AZA, CYC, MMF | Spontaneous planned pregnancy (35 years; HCQ, AZA, PD; severe lupus flare during pregnancy. Alive, term (38+ 2w), 2420g, Apgar 9-10 | 35 SLEDAI 7 | PD 60 mg/day, HCQ 400 mg, AZA 150 mg | Remission SLEDAI 0 | HCQ 200 mg, vitamin D |
| 2 | 14 | Rash malar, Raynaud, HA, myalgias, asthenia, low complements, dsDNA. | PD, HCQ, AZA, MMF, RTX | Spontaneous non-planned pregnancy (30 years), pregnancy loss at 16 w. PD, HCQ, AZA, lupus flare later | 31 SLEDAI 12 | PD 5 mg/day, HCQ 400 mg MMF 2 g | Slight low complement SLEDAI 2 | PD 5 mg/day, HCQ 200 mg, vitamin D |
| 3 | 14 | Polyarthritis, chorea, LN (type V GN), low complements, dsDNA, APA. | PD, MPA, HCQ, OA | No | 28 SLEDAI 17 | HCQ 300 mg, MPA 1440 mg, PD 2.5 mg, OA | Positive dsDNA SLEDAI 2 | HCQ 300, OA, vitamin D |
| 4 | 21 | Myositis, pancitopenia, LN (type IV GN), polyarticular arthritis, dsDNA, low complements | PD, AZA, CY-A, HCQ, CYC | Spontaneous planned pregnancy (32 years), HCQ, AZA, LDA. Alive, term (39+ 5w), vaginal delivery, 3080, Apgar 9-10 | 36 SLEDAI 10 | HCQ 400 mg, AZA 150 mg, LDA 100 mg, vitamin D | Positive dsDNA SLEDAI 2 | HCQ 400 mg, AZA 150 mg, LDA 100 mg, vitamin D |
| 5 | 14 | Polyarticular arthritis, HA, lymphopenia, rash, LN (type IV GN), vasculitis, ischaemic cerebral lesion, aseptic meningitis, dsDNA, low complements, APA | PD, CYC, MMF, RTX, AZA | No | 36 SLEDAI 10 | LDA 100 mg, HCQ 200 mg, AZA 100 mg, PD 5 mg/day | Positive dsDNA SLEDAI 2 | LDA 100, HCQ 200, AZA 50 |
| 6 | 23 | Rash, polyarticular arthritis, raynaud, oral ulcers, overlap MCTD | PD, HCQ, MTX | No | 31 SLEDAI 6 | MTX 10 mg/w, PD 5 mg, HCQ 200 mg, LDA 100 mg | Remission SLEDAI 0 | LDA 100 mg, PD 2.5 mg/day, HCQ 200 mg, vitamin D |
| 7 | 9 | Severe subacute cutaneous lupus, thrombopenia, pleuritis, dsDNA, low complements | PD, HCQ, AZA, isotretinoin | Spontaneous planned pregnancy (33 years), atebrine, HCQ, MMF, PD. Alive, term (38 w) caesarean section (non-deliver-progression), 2580 g, Apgar 9-10 | ||||
| 8 | 21 | LN (type IV), low complements, dsDNA, APA | PD, CYC, AZA | 3 pregnancy loses (1 chemical pregnancy, 1 in w 7, 1 in w 11) | ||||
| 9 | 29 | Fever, polyarthritis, transverse myelitis, lymphadenopathy, LN (type III GN). Low complements, dsDNA. | AZA, CYC, MP, PD, MMF, RTX | No | ||||
| 10 | 23 | Polyarticular arthritis, APA, dsDNA, low complements, LN (type IV GN) | MMF, HCQ, LDA, PD | No | ||||
| 11 | 42 | Fever, arthralgias, oral ulcers, dsDNA, APA | 4 pregnancies pre-LES diagnosis | |||||
| 12 | 17 | Thrombopenia, APA, dsDNA, low complements, LN (type IV GN) | MMF, HCQ, LDA, PD, CYC | 1 induced abortion at 16 years old |
APA, antiphospholipid antibodies; ART, Assisted Reproductive Technology; AZA, azathioprine; BEL, belimumab; HCQ, hydroxychloroquine; GN, glomerulonephritis; HA, haemolytic anaemia; IVIg, intravenous immunoglobulin therapy; LDA, low dose aspirin; LMWH, low molecular weight heparin; LN, lupus nephritis; MMF, mycophenolate mofetil; MPA, mycophenolic acid; MCTD, mixed connective tissue disease; MTX, methotrexate; OA, oral anticoagulants; PD, prednisone; W, weeks; Y, years.