Table 2.
Univariate and multivariate analyses of factors associated with overall survival
| Characteristics | Total (N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| Histological type | 669 | ||||
| Glioblastoma | 160 | Reference | |||
| Astrocytoma | 192 | 0.151 (0.109–0.209) | <0.001 | 0.144 (0.044–0.473) | 0.001 |
| Oligoastrocytoma | 128 | 0.093 (0.060–0.144) | <0.001 | 0.160 (0.047–0.543) | 0.003 |
| Oligodendroglioma | 189 | 0.085 (0.058–0.124) | <0.001 | 0.107 (0.032–0.360) | <0.001 |
| Age | 669 | ||||
| ≤60 | 530 | Reference | |||
| >60 | 139 | 4.716 (3.609–6.161) | <0.001 | 4.004 (2.370–6.763) | <0.001 |
| Primary therapy outcome | 443 | ||||
| PD | 103 | Reference | |||
| SD | 144 | 0.381 (0.250–0.580) | <0.001 | 0.373 (0.222–0.628) | <0.001 |
| PR | 62 | 0.138 (0.055–0.342) | <0.001 | 0.191 (0.067–0.541) | 0.002 |
| CR | 134 | 0.131 (0.063–0.274) | <0.001 | 0.175 (0.081–0.380) | <0.001 |
| IDH status | 660 | ||||
| WT | 237 | Reference | |||
| Mut | 423 | 0.102 (0.077–0.135) | <0.001 | 0.404 (0.228–0.717) | 0.002 |
| 1p/19q codeletion | 663 | ||||
| Codel | 167 | Reference | |||
| Non-codel | 496 | 4.635 (2.963–7.251) | <0.001 | 1.122 (0.567–2.220) | 0.740 |
| WHO grade | 612 | ||||
| G2 | 215 | Reference | |||
| G3 | 237 | 3.102 (2.030–4.739) | <0.001 | 1.911 (1.161–3.147) | 0.011 |
| G4 | 160 | 19.164 (12.573–29.209) | <0.001 | ||
| DNAJC1 | 669 | ||||
| Low | 334 | Reference | |||
| High | 335 | 2.295 (1.771–2.974) | <0.001 | 1.064 (0.667–1.698) | 0.795 |