Table 1.

Topical Formulations with Cannabidiol

Formula / Authors / Country / Year	Formula Composition	Therapeutic Target	Description	Results
Ke yin fang Iliev and Broshtilova China 200371	Radix Rehmanniae Glutinosae 30g, Radix Scrophulariae ningpoensis 30g, Semen Cannabis sativae 10g, Rhizoma Menisperi daurici 10g, Radix Sophorae flavescentis 10g	Overcome Psoriasis Formula to treat Blood Dryness induced psoriasis in traditional Chinese medicine	Not reported	Not reported
Formulation for dry acute dermatitis Hadji-Minaglou and Bolcato France 200572	E.O. Syzygium aromaticum 0.01 g E.O. Cedrus deodara 0.3 g E.O. Eucalyptus radiata 0.3 g E.O. Cannabis sativa 0.03 g E.O. Mentha citrata 0.03 g Vitamin E 0.3g Vaseline Q.S.P 100.00 grs	The goals of these formulation were to control the acute phase of eczema and psoriasis whilst managing the inflammatory phase.	A lipophilic pommade, in a hydrophobic Vaseline base, adding the essential oils. This product can be put into an aluminium tube, and a small nub of the product is applied to the inflamed region three times per day at regular intervals. The duration of treatment does not exceed 5 days. The study included a total of 45 patients over nine months.	The results show the disappearance of itching within 3–30 min following application and a steady reduction in inflammation (2–12 h), characterised by a reduction in pain, oedema and marked blocking of the sensation of heat.
Shampoo Containing Broad-Spectrum Cannabidiol Vincenzi and Tosti Italy/USA 202073	0.075% broad-spectrum cannabidiol Ketoconazole Ingredients that promote hair growth	Efficacy and Tolerability of a Shampoo Containing Broad-Spectrum Cannabidiol in the Treatment of Scalp Inflammation in Patients with Mild to Moderate Scalp Psoriasis or Seborrheic Dermatitis	Age of inclusion 18–65 years with mild to moderate scalp psoriasis or SD. The shampoo was used daily for 14 days. Twenty-two subjects had scalp psoriasis and 28 subjects SD	No side effects reported. The study shown the shampoo to be highly effective in reducing signs of scalp inflammation as well as reducing symptoms of erythema and scaling, itching, and burning, following 2 weeks’ use.
A method to treat psoriasis Changoer and Anastassov USA 201974	CBD/CBG oil had CBD and CBG, in combination, at 3% by weight of the total composition CBD/CBG oil had CBD and CBG, in combination, at 15% by weight of the total composition	Intervention to treat psoriasis	Two psoriasis patients. Subjects received treatment twice daily for six weeks. In both patients, both the 15% and the 3% concentrations were administered cutaneously on different areas of the body affected by psoriasis	CBG/CBD oil significantly reduces the symptoms of psoriasis. It seems to be a clear dose-response effect (15% CBD/CBG oil vs 3% CBD/CBG oil). Treatment by 3% CBG/CBD oil treatment showed no improvement on the lesions. The 15% CBG/CBD oil treatment showed 16% improvement on Subject 1 and 33% improvement on Subject 2 with psoriasis vulgaris.
Report of a Case - Topical Cannabinoids for the Management of Psoriasis Vulgaris Friedman et al USA 202075	Tetrahydrocannabinol (THC) distillate cream with medium chain triglyceride (MCT) oil, beeswax, and sunflower lecithin, THC soap infused with a scent-free hemp soap, 5 mg/mL, and a hair oil with THC distillate dissolved into jojoba oil, 5 mg/mL.	Psoriasis	The patient was advised to apply the cream and oil to patches on body skin and to use the oil on the hair-baring areas daily as well as to use the soap when showering.	The patient reported improvement within two days of initiating this regimen. Seven months after initial use, the patient reported that he continues to use the products regularly for maintenance