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. 2024 Apr 10;52(11):6171–6182. doi: 10.1093/nar/gkae239

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© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Transcriptional landscape of HELLS in T-cell Lymphomas. (A) Schematic workflow for the identification of HELLS direct genes (HDGs). (B) GO enrichment bar plot of the most significantly enriched pathways (adjusted P-value < 0.05) for HDGs. Colors indicate the adjusted P-values and the size of bars is proportional to the ratio of differentially expressed genes on the total genes of the given pathway. (C) Outline of the study workflow for validating HELLS signature in the FFPE retrospective cohorts of ALCL by the nCounter platform. (D) Correlation plots of HELLS and a selection of HDGs in ALK⁻ ALCL and ALK⁺ ALCL patients. For each gene pair, the expression HELLS is on the x-axis, while the expression HDGs is on the y-axis. Blue and red areas represent 95% confidence intervals.