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. 2024 Mar 30;52(11):6596–6613. doi: 10.1093/nar/gkae220

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© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — AR-FL and V7 pre-mRNA transcript diagrams drawn to scale. These diagrams show the differences in size and sequence/functional domains between the two isoforms. AR-FL pre-mRNA and mature transcript (ENST00000374690.9) are displayed on top and AR-V7 pre-mRNA and mature transcript (ENST00000504326.5) are displayed on the bottom. The AR-FL pre-mRNA is 186598 nt long, and the mature transcript is 10667 nt long, consisting of a 1126 nt 5′UTR, a 2763 nt CDS, and a 6778 nt 3′UTR. The AR-V7 pre-mRNA is 151452 nt long and the mature transcript is 3615 nt long, consisting of a 327 nt 5′UTR, 1935 nt CDS, and a 1353 nt 3′UTR. Although much shorter, the V7 isoform encodes a constitutively active version of the AR protein caused by a truncated ligand binding domain. Here, shared UTR sequences are displayed in orange and shared CDS sequences are displayed in blue, green, yellow, and purple. Unique UTR sequences are displayed in gray and unique CDS sequences are displayed in pink.