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. 2024 May 13;52(11):6707–6717. doi: 10.1093/nar/gkae376

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© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Interactions of ANP77 with G₂C₄ RNA. (A, B) chemical structure of the ANP77 molecule: (A) in single and (B) double-protonated state. (C) Stacked conformation of ANP77 observed in the crystal structure. Selected atoms are indicated (see text for details). (D) secondary structure of G₂C₄–ANP77 complex. Green lines represent ANP77 ligand. (E, F) Pseudo-canonical base-pairs formed between ANP77 (green) and cytosine residues from chain A (cyan). (G) Base triple between cytosine from chain C (purple), guanosine from chain A (cyan), and cytosine from chain B (cyan). (H) Crystal model of RNA tetramer (chain A and B in cyan; chain C and D in pink) with bound ligand molecule (green sticks). The 2Fo–Fc electron density map (gray) is contoured at the 1σ level. The H-bonds are represented by black dashed lines.