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. 2024 Jun 24;12:37. doi: 10.1038/s41413-024-00345-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Fgfr1 is expressed in Gli1⁺ progenitor cells and their progeny during tooth root development. a–h Expression of Fgfr1 in mandibular first molars from wild-type mice at PN3.5, PN7.5, PN14 and PN28. White arrows point to the expression of Fgfr1 in apical papilla and odontoblasts; yellow arrows point to the expression of Fgfr1 in follicle cells. i–l Expression of Fgfr1 and tdTomato at PN18 in Gli1-Cre^ER;tdT mouse model. White arrows point to the expression of Fgfr1 in periodontal ligament; white arrowheads point to the expression of Fgfr1 in odontoblasts. PDL, periodontal ligament; OD, odontoblasts; DPC, dental pulp cells. White dashed lines outline Hertwig’s epithelial root sheath (HERS). Scale bars, 100 μm