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. 2024 Jun 10;15:1397072. doi: 10.3389/fimmu.2024.1397072

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Copyright © 2024 Heine, Alessandrini, Grosch, Graß, Heldner, Schnautz, Grosch, Buters, Slusarenko, Krappmann, Fallarino, Ohnmacht, Schmidt-Weber and Blank

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of experimental AIT on immunoglobulin titers in wild-type vs. AhR^-/- mice. Analysis of total IgE, OVA-sIgE, total IgG1, and OVA-sIgG1 in serum samples collected at the end (day 64) of the experiment (n = 5). Data analyzed with 2-way ANOVA with Tukey’s multiple comparisons test or Sidak’s multiple comparisons test, respectively. The bar charts show the mean with standard deviation. p-values of ≤.05, ≤.01, ≤.001, and ≤.0001 are shown as *, **, ***, and ****, respectively. AhR^-/-, aryl hydrocarbon receptor knockout; AIT, allergen-specific immunotherapy; Ig, immunoglobulin; OVA, ovalbumin; sIg, specific immunoglobulin.