Figure 6.

Effect of experimental AIT and 10-Cl-BBQ treatment on the expression of the AhR target gene Cyp1a1 in murine lung tissue. (A) Gene expression analysis of Cyp1a1 in lung tissue 24 h after the last 10-Cl-BBQ administration (day 43; Figure 1B ); (n = 5 – 8). (B) Gene expression analysis of Cyp1a1 in lung tissue 22 days after the last 10-Cl-BBQ administration and an additional OVA challenge phase (day 44; Figure 1C ); (n = 10 – 13). Data analyzed by 1-way ANOVA with Tukey’s test. Data is displayed as box plots with whiskers indicating 1-99 percentile. p-values of ≤.01, ≤.001, and ≤.0001 are shown as **, ***, and ****, respectively. AIT, allergen-specific immunotherapy; BQ, 10-Cl-BBQ; Cyp1a1, Cytochrome P450 Family 1 Subfamily A Member 1.