Figure 3.

αMβ2 and TLR4 crosstalk The crosstalk between αMβ2 and TLR4 is shown.Inside-out signal: LPS binding to TLR4 induces the activation of many molecules including PI3K. PI3K facilitates the activation of αMβ2 intracellular adaptor proteins, therefore αMβ2 itself. Outside-in signal: Activated αMβ2 communicates with Src/Syk, which facilitates the degradation of MyD88 and TRIF. This will attenuate TLR4 activation signal. Of note, Syk is typically associated with other receptors like C-type lectin receptors (CLRs).