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. 2024 Jun 10;15:1403764. doi: 10.3389/fimmu.2024.1403764

Table 2.

List of integrins, their ligands and expression distribution (4851).

Integrins Ligands Expression
α1β1 Laminin, Collagen I, Collagen IV Activated T and B cells, NK cell, glial cell, Schwann cells, fibroblasts, endothelium
α2β1 Laminin, Collagen, Tenascin Activated T and B cells, NK cell, cell, fibroblasts, endothelium, epithelium
α3β1 Laminin, Fibronectin Activated T cells, thymocytes, astrocytes, fibroblasts, endothelium, epithelium
α4β1 Fibronectin, VCAM-1, MAdCAM-1, TSP-1, Osteopontin, T and B cells, NK cell, eosinophils, fibroblasts, endothelium
α5β1 Fibronectin, murine L1 Activated T and B cells, thymocytes, platelets, astrocytes, fibroblasts, endothelium, epithelium
αVβ1 Vitronectin, Fibronectin, Collagen, Fibrinogen, von Willebrand factor Oligodendroglia
α6β1 Laminin T cells, thymocytes, glial cell, fibroblasts, endothelium, epithelium
α7β1 Laminin Melanoma, skeletal and cardiac muscle
α8β1 Fibronectin, Vitronectin, Tenascin Neurons, oligodendroglia, epithelium
α9β1 Osteopontin, Tenascin, VCAM-1, Fibronectin, ADAM, VEGF Epithelium (airway), muscle
α10β1 Collagen Chondrocyte, mesenchymal stem cell
α11β1 Collagen Skeletal and smooth muscle
αLβ2 ICAM-1, ICAM-2, ICAM-3 T cells, leucocytes, thymocytes,
αMβ2 ICAM-1, Factor X, iC3b, Fibrinogen NK cell, activated B cell, myeloid cell, macrophage
αXβ2 iC3b, Fibrinogen Activated B cell, myeloid cell, dendritic cell, macrophage
αDβ2 ICAM-1, ICAM-3, VCAM-1 Myeloid cell
αIIβ3 Fibronectin, Vitronectin, von Willebrand factor, Thrombospondin, Fibrinogen Platelets
αVβ3 Fibronectin, Osteopontin, von Willebrand factor, PE-CAM-1, Vitronectin, human L1, Thrombospondin, Collagen Activated T and B cells, monocytes, endothelium, glia
α6β4 Laminin Schwann cell, endothelium, epithelium, fibroblasts
αVβ5 Vitronectin, Fibronectin, Fibrinogen Monocytes, macrophages, oligodendroglia, epithelium, fibroblasts
αVβ6 Fibronectin Epithelium
α4β7 Fibronectin, VCAM-1, MAdCAM-1 NK cell, T and B cell
αEβ7 E-cadherin Intraepithelial T lymphocyte
αVβ8 Fibronectin, Vitronectin Schwann cell, oligodendroglia, brain synapses