Chen 2011.

Methods	Study design: randomised controlled trial. Method of randomisation: random number table. Concealment of allocation: no description. Exclusions post randomisation: none. Length of follow‐up: 6 months. Losses to follow‐up: none. Intention‐to‐treat analysis: not mentioned.
Participants	Patients were all diagnosed as having ACS based on coronary arteriography, and in accordance with the diagnostic criteria formulated by the European Society of Cardiology in September 2000. Tong‐xin‐luo group: 80 patients (male/female: 48/32; age: 71.5 ± 5.6 years). Control group: 80 patients (male/female: 46/34; age: 70.7 ± 5.8 years).
Interventions	Control: conventional treatment (pre‐operation: aspirin 100 mg qd, clopidogrel 75 mg qd; post‐operation: aspirin, clopidogrel, nitroglycerin, low molecular weight heparin, ACEI, atorvastatin). Tong‐xin‐luo group: conventional treatment plus Tong‐xin‐luo capsules (4 capsules tid; 0.26 g/capsule). Duration of intervention: 6 months.
Outcomes	Occurrence of angiographic restenosis; Occurrence of heart failure and angina.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomised, random number table was used.
Allocation concealment (selection bias)	Unclear risk	No description about the allocation procedure.
Blinding of participants and personnel (performance bias) All outcomes	High risk	No description about blinding. No placebo.
Blinding of outcome assessment (detection bias) All outcomes	High risk	No description about blinding. No placebo.
Incomplete outcome data (attrition bias) Angiographic restenosis	Low risk	Same numbers of participants randomly assigned and analysed. No missing outcome data.
Incomplete outcome data (attrition bias) Outcomes other than angiographic restenosis	Low risk	Same numbers of participants randomly assigned and analysed. No missing outcome data.
Selective reporting (reporting bias)	Unclear risk	The study protocol is not available.
Other bias	Low risk	Baseline characteristics (sex, age, type of angina, disease severity, disease duration, comorbidities, blood glucose, blood pressure, serum lipoid, etc.) were comparable between the two groups (P > 0.05). The study appeared to be free of other sources of bias.