Wu 2010.

Methods	Study design: randomised controlled trial. Method of randomisation: no description. Concealment of allocation: no description. Exclusions post randomisation: none. Length of follow‐up: 6 months. Losses to follow‐up: none. Intention‐to‐treat analysis: not mentioned.
Participants	Participants were patients with unstable angina based on the Unstable Angina Diagnosis and Treatment Guidelines formulated by the Chinese Society of Cardiology of the Chinese Medical Doctors Associations in 2007, and underwent PCI successfully. Tong‐xin‐luo group: 57 patients (male/female: 32/25; age: 71.4 ± 4.5 years). Control group: 53 patients (male/female: 31/22; age: 69.8 ± 4.3 years).
Interventions	Control: conventional treatment: • Pre‐operation: aspirin 100 mg qd, clopidogrel 75 mg qd for more than 7 days. • Post‐operation: aspirin, clopidogrel, nitroglycerin, low molecular weight heparin, ACEI, etc. Tong‐xin‐luo group: conventional treatment plus Tong‐xin‐luo capsules (4 capsules, tid; 0.38 g/capsule) Duration of intervention: 6 months. Co‐intervention: none.
Outcomes	Occurrence of angiographic restenosis; Occurrence of myocardial infarction, heart failure and angina; Use of revascularisation, including PCI and coronary artery bypass graft surgery.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomised, but detailed information on the randomisation method was not provided.
Allocation concealment (selection bias)	Unclear risk	No description about the allocation procedure.
Blinding of participants and personnel (performance bias) All outcomes	High risk	No description about blinding. No placebo.
Blinding of outcome assessment (detection bias) All outcomes	High risk	No description about blinding. No placebo.
Incomplete outcome data (attrition bias) Angiographic restenosis	Unclear risk	Whether all participants were brought back for angiography was not reported.
Incomplete outcome data (attrition bias) Outcomes other than angiographic restenosis	Low risk	There was no loss to follow‐up.
Selective reporting (reporting bias)	Unclear risk	The study protocol is not available.
Other bias	Low risk	Baseline information showed no statistical differences in sex, age, comorbidities, number and distributions of coronary pathological changes, blood pressure, levels of blood glucose and levels of blood lipoid between the two groups (P > 0.05). The study appeared to be free of other sources of bias.