Han 2012.
Trial name or title | Tongxinluo Improve High on Clopidogrel Platelet Reactivityn Patients With Coronary Heart Disease |
Methods | Randomised double‐blind trial |
Participants | ACS (including unstable angina pectoris, non‐ST‐segment elevation myocardial infarction and ST‐elevation myocardial infarction; at least one coronary stent; age between18 and 75; high on‐treatment platelet reactivity defined as an ADP‐induced platelet aggregation (by VerifyNow, PRU ≥ 236) at 24 hours after clopidogrel loading (300 ‐ 600 mg) or 24 hours after PCI. |
Interventions | Tong‐xin‐luo |
Outcomes | Platelet aggregation rate; Inflammation Marker (hsCRP, CD62P‐CD41); BT, FIB and aPTT; Major ischemic event (including MI, ischemic stroke and all‐cause mortality); Bleeding event; Adverse drug reaction and withdrawal rate; Angina recurrence; Traditional Chinese medicine angina symptoms scores; Intra‐stent thrombosis. |
Starting date | November 1, 2012 |
Contact information | Yaling Han, MD Tel: +86‐24‐23922184 E‐mail: 13998847715@qq.com |
Notes |
Abbreviations
ACS: acute coronary syndrome PRU: P2Y12 reactivity unit PCI: percutaneous coronary intervention aPTT: activated partial thromboplastin time MI: miocardial infarction