Figure 2. 3D genome structure changes upon estrogen treatment associate with differential gene expression.

A) Overlap is shown between E2 upregulated or downregulated genes (purple) and all genes involved with differential 3D interactions (pink) in Ishikawa cells. (B-C) Boxplots demonstrate relative expression of E2 upregulated (B) and downregulated (C) genes associated with increasing (B) or decreasing (C) 3D genome interactions in Ishikawa cells, respectively. P-values are from t-test on the linear regression coefficient being different from 0. D) The GSEA rank of hallmark gene set enrichments based on the number of 3D genome interactions within 100 kb of each gene’s TSS in Ishikawa cells is shown.