TABLE 1.
Clinical history of LTNPs
| LTNP | Date of first seropositivity detectiona (mo-day-yr or yr) | Date of last visitb (mo-day-yr or mo-yr) | Absolute CD4 T-cell counts/ml at last visit | Plasma viral RNA level at last visit (copies/ml) |
|---|---|---|---|---|
| LTNP 1 | 12-21-83 | 2-11-99 | 257c | <50 |
| LTNP 2 | 3-7-84 | 9-16-98 | 589 | 58 |
| LTNP 3 | 12-7-83 | 4-21-99 | 530 | 180 |
| LTNP 5 | 2-1-84 | 3-2-95 | 464 | 644 |
| LTNP 6 | 5-16-84 | 3-24-99 | 1,122 | 5,000 |
| LTNP 7 | 2-29-84 | 1-6-99 | 606 | 97 |
| 161J | 1979 | 6-15-99 | 843 | <50 |
| 1486D | 1991 | 12-98 | 630 | 8,360 |
a
LTNP 1, LTNP 2, LTNP 3, LTNP 6, and LTNP 7 were all seropositive at their first visit. LTNP 5, 161J, and 1486D seroconverted between regularly scheduled visits.
b
The date shown is the date of the last visit. LTNP 5 died from complications of hepatitis C infection in June 1997. All other patients are healthy as of their last visit.
c
CD4 T-cell counts in LTNP 1, who is infected with Nef-deleted HIV-1, began declining around 1996 to 1997 despite consistently undetectable viral loads (19).