a, Schematic of the elevated platform test.
b, Average calcium trace during elevated platform
assessment, and corresponding area under curve (AUC) analysis. Paired
two-sided t-test, P = 0.0017. n = 4 mice.
c, Schematic of the elevated plus maze. d,
Average calcium trace during the seconds immediately preceding and following
open arm entry and exit, with corresponding AUC analysis. Paired two-sided
t-test, P < 0.0001. n = 4 mice.
e, Calcium traces from individual animals. Pink shading
indicates when mice were in the open arm. n = 4 mice. Data are presented as
the mean ± SEM; see also Supplementary Table 3 for statistical
details. **P<0.01,
***P<0.001.