Table 2.

TME features associated with response to CAR-19 therapy.

Study	Sample collection	TME features associated with CR	TME features associated with PD
Locke et al. [13]	Infusion product	NR	High TB, myeloid activation markers, excess type 1 cytokines
Chen et al. [42]	Pre/post CAR-T biopsies	Non-CAR activated T-cells	Non-CAR lymphocytes/monocytes producing IL-6
Jain et al. [16]	Pre CAR-T biopsies	NR	Macrophage infiltration, peripheral blood M-MDSCs, high ferritin, CRP, and IL-6
Scholler et al. [26]	Pre/post CAR-T biopsies	PD1 + LAG3+/−TIM3-CD8+ cells; modest Tregs; high IL-15, IL-17, IL-18, IL-21	NR

Abbreviations: CR: complete response; PD: progressive disease; M-MDSC: monocytic myeloid derived suppressor cell; NR: not reported.