Table 5 •.
Hierarchical Linear Regression Models of Predictors of the QOL Dimensions
| QOL Dimensions | Predictors | Model 1 |
Model 2 |
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|---|---|---|---|---|---|---|---|---|---|
| B (95% CI) | SE B | β | P | B (95% CI) | SE B | β | P | ||
|
| |||||||||
| Role limitations due to physical health | Intercept | 14.72 (−25.58, 55.01) | 20.20 | .469 | 25.95 (−13.42, 65.31) | 19.73 | .193 | ||
| Age | 0.05 (−0.66, 0.76) | 0.35 | 0.02 | .893 | −0.54 (−1.34, 0.26) | 0.40 | −0.20 | .181 | |
| Race a (Ref: White) | |||||||||
| Black | 5.01 (−12.00, 22.02) | 8.53 | 0.07 | .559 | 8.16 (−8.27, 24.57) | 8.23 | 0.12 | .325 | |
| Other | −18.72 (−72.37, 34.93) | 26.89 | −0.09 | .489 | −18.75 (−70.03, 32.53) | 25.70 | −0.09 | .468 | |
| ECOG | 1.49 (−7.63, 10.60) | 4.57 | 0.04 | .746 | 0.28 (−8.47, 9.03) | 4.39 | 0.01 | .949 | |
| COST totala | 1.31 (0.36, 2.26) | 0.48 | 0.38 | .008 b | |||||
|
| |||||||||
| Model summary | R2 = 0.02; adjusted R2 = −0.04; F = 0.33 | R2 = 0.12; adjusted R2 = 0.05; ΔR2 = 0.10 b; F = 1.80 | |||||||
|
| |||||||||
| Pain | Intercept | 32.92 (4.62, 61.23) | 14.19 | .023 | 41.71 (14.40, 69.03) | 13.69 | .003 | ||
| Age | 0.29 (−0.21, 0.79) | 0.25 | 0.14 | .247 | −0.17 (−0.73, 0.38) | 0.28 | −0.08 | .539 | |
| Race (Ref: White) | |||||||||
| Black | −5.01 (−16.92, 6.89) | 5.97 | −0.10 | .404 | −2.56 (−13.90, 8.79) | 5.69 | −0.05 | .654 | |
| Other | −6.63 (−44.48, 31.22) | 18.98 | −0.04 | .728 | −6.64 (−42.37, 29.09) | 17.91 | −0.04 | .712 | |
| ECOG a | −6.38 (−12.81, 0.06) | 3.22 | −0.24 | .052 | −7.32 (−13.42, −1.22) | 3.06 | −0.27 | .019 c | |
| COST total a | 1.03 (0.37, 1.69) | 0.33 | 0.41 | .003b | |||||
|
| |||||||||
| Model summary | R2 = 0.08; adjusted R2 = 0.03; F = 1.58 | R2 = 0.20; adjusted R2 = 0.14; ΔR2 = 0.11b; F = 3.34 b | |||||||
|
| |||||||||
| Role limitations due to emotional problems | Intercept | −7.15 (−53.49, 39.20) | 23.24 | .759 | 0.88 (−45.94, 47.69) | 23.47 | .970 | ||
| Age | 0.81 (0.00, 1.62) | 0.41 | 0.25 | .051 | 0.39 (−0.56, 1.34) | 0.48 | 0.12 | .419 | |
| Race (Ref: White) | |||||||||
| Black | −0.95 (−20.43, 18.53) | 9.77 | −0.01 | .923 | 1.29 (−18.15, 20.73) | 9.75 | 0.02 | .895 | |
| Other | −0.08 (−62.05, 61.89) | 31.07 | 0.00 | .998 | −0.09 (−61.33, 61.15) | 30.70 | 0.00 | .998 | |
| ECOG | −4.06 (−14.59, 6.47) | 5.28 | −0.09 | .445 | −4.92 (−15.38, 5.53) | 5.24 | −0.11 | .351 | |
| COST totala | 0.94 (−0.20, 2.07) | 0.57 | 0.23 | .104 | |||||
|
| |||||||||
| Model summary | R2 = 0.06; adjusted R2 = 0.01; F = 1.11 | R2 = 0.10; adjusted R2 = 0.03; ΔR2 = 0.04; F = 1.45 | |||||||
|
| |||||||||
| Emotional well-being | Intercept | 38.38 (16.26, 60.51) | 11.09 | .001 | 43.92 (22.05, 65.79) | 10.96 | <.001 | ||
| Age a | 0.53 (0.14, 0.92) | 0.19 | 0.32 | .008 b | 0.24 (−0.21, 0.68) | 0.22 | 0.15 | .288 | |
| Race (Ref: White) | |||||||||
| Black | −3.72 (−13.03, 5.58) | 4.66 | −0.09 | .427 | −2.18 (−11.26, 6.90) | 4.55 | −0.05 | .634 | |
| Other | −12.70 (−42.29, 16.88) | 14.83 | −0.10 | .395 | −12.71 (−41.32, 15.89) | 14.34 | −0.10 | .378 | |
| ECOG | −2.20 (−7.23, 2.83) | 2.52 | −0.10 | .386 | −2.80 (−7.68, 2.09) | 2.45 | −0.13 | .257 | |
| COST totala | 0.65 (0.12, 1.18) | 0.27 | 0.32 | .017 c | |||||
| Model summary | R2 = 0.13; adjusted R2 = 0.08; F = 2.67 c | R2 = 0.20; adjusted R2 = 0.14; ΔR2 = 0.07c; F = 3.48 b | |||||||
Abbreviations: ΔR2, the change in R2; β, standardized coefficient; B, unstandardized coefficients; CI, confidence interval; COST, COmphrehensive Score for financial Toxicity; ECOG, Eastern Cooperative Oncology Group; QOL, quality of life; R2, coefficient of Determination; Ref, reference value.
a
Predictor(s) had a statistically significant association with the outcome variable in bivariate analysis (P < .05).
b
P < .01.
c
P < .05.