Table 3.
Age (years) | Gender | Baseline QMG | Baseline MG-ADL | Follow-up QMG | Follow-up MG-ADL | Baseline therapy | Follow-up therapy | Baseline ITIH3 (ng/ml) | Follow-up ITIH3 (ng/ml) | Follow-up time point (months) | Steroids (mg/day) | Responder |
---|---|---|---|---|---|---|---|---|---|---|---|---|
43 | f | 9 | 11 | 9 | 6 | MMF | AZA | 1592.849 | 890.391 | 8 | 0 | Yes |
68 | m | 13 | 8 | 13 | 5 | Naïve | MTX | 1203.973 | 832.151 | 4 | 5 | Yes |
54 | m | 10 | 25 | 4 | 8 | Naïve | ECU | 561.49 | 950.29 | 6 | 5 | Yes |
28 | f | 16 | 24 | 12 | 16 | Naïve | EFG | 1543.299 | 748.127 | 6 | 5 | Yes |
54 | m | 12 | 7 | 4 | 2 | RTX | ECU | 684.299 | 291.227 | 8 | 0 | Yes |
62 | f | 22 | 30 | 12 | 16 | Naïve | ECU | 1832.291 | 983.221 | 6 | 2.5 | Yes |
21 | f | 6 | 12 | 7 | 9 | Naïve | AZA | 890.829 | 560.322 | 6 | 5 | Yes |
32 | f | 12 | 18 | 8 | 12 | Naïve | ECU | 1993.289 | 482.991 | 6 | 0 | Yes |
68 | m | 20 | 19 | 2 | 3 | AZA | ECU | 1693.289 | 493.392 | 6 | 0 | Yes |
36 | f | 10 | 12 | 7 | 6 | Naïve | EFG | 1294.299 | 439.29 | 6 | 2.5 | Yes |
66 | m | 15 | 4 | 15 | 11 | Naïve | AZA | 792.382 | 827.382 | 4 | 5 | No |
61 | m | 2 | 3 | 2 | 3 | MMF | AZA | 178.299 | 114.293 | 4 | 7,5 | no |
73 | m | 10 | 4 | 10 | 3 | MMF | AZA | 672.407 | 635.495 | 4 | 0 | no |
37 | f | 1 | 3 | 1 | 2 | Naïve | AZA | 359.8676 | 325.841 | 4 | 0 | no |
31 | f | 13 | 11 | 13 | 12 | Naïve | RTX | 625.291 | 389.211 | 6 | 10 | no |
66 | m | 2 | 5 | 6 | 5 | AZA | ECU | 522.832 | 581.74 | 4 | 5 | no |
32 | f | 3 | 8 | 3 | 8 | Naïve | AZA | 798.299 | 438.128 | 6 | 0 | no |
Individual clinical and demographic data of follow-up patients. MG patients were defined as treatment responders if they improved by ≥ 3 points on the MG-ADL scale. ITIH3 levels were measured in serum samples by ELISA. All patients were anti-AChR-Ab positive
AChR acetylcholine receptor, Ab antibody, AZA azathioprine, ECU eculizumab, EFG efgartigimod, f female, ITIH3 inter-alpha-trypsin inhibitor heavy chain H3, m male, MG-ADL myasthenia gravis activities of daily living, MMF mycophenolate-mofetil, MTX methotrexate, QMG quantitative myasthenia gravis, RTX rituximab