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. 2024 Jun 20;17:4001–4016. doi: 10.2147/JIR.S474879

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© 2024 Xu et al.

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Function of IL-37 in different immune cells. IL-37 inhibits expression of inflammatory components such as iNOS, IL-6, MCP-1, ROS in macrophages, and promotes expression of IL-10, GPX4, NRF2, CD206. IL-37 inhibits dendritic cells maturation, including downregulation of expression of MHCII, CD40, CD86, CD80. IL-37 suppresses infiltration of basophils, and Th17, Tfh cells differentiation, proliferation, whereas it promotes Th1, Treg cells differentiation. IL-37 is able to inhibit B cells production of IgG.

Abbreviations: iNOS, inducible nitric oxide synthase; IL-6, interleukin-6; MCP-1, monocyte chemoattractant protein 1; ROS, reactive oxygen species; GPX4, glutathione peroxidase 4; NRF2, nuclear translocation of NF-E2-Related Factor 2; MHCII, major histocompatibility complex class II; Th17 cell, T helper 17 cell; Tfh cell, follicular T helper cell; Treg cell, regulatory T cell.