Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jun 20;17:4001–4016. doi: 10.2147/JIR.S474879

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2024 Xu et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

In vivo effects of IL-36, IL-37 and IL-38 on OA development. Injection of IL-36Ra inhibited Tgfbr2^−/− spontaneous OA mice synovitis, whereas injection of IL-36α promoted OA development. In DMM-induced OA mice, injection of IL-36Ra or IL-36Ra@Gel suppressed severity of cartilage tissue destruction. On the contrary, injection of IL-36α exacerbated OA progress. For IL-37, injection of IL-37 into TMJOA rats suppressed swelling and hyperplasia in tissues around the cartilage. Regarding role of IL-38, DMM-induced OA mice injected with overexpressed IL-38 significantly improved cartilage damage, downregulated OARSI score.

Abbreviations: OA, osteoarthritis; DMM, destabilization of the medial meniscus; IL-36Ra@Gel, poly(lactic-co-glycolic acid)-poly(ethyleneglycol)-poly(lactic-co-glycolic acid) (PLGA-PEG-PLGA) hydrogel system incorporating IL-36Ra; TMJOA, temporomandibular joint OA; OARSI, Osteoarthritis Research Society International.