TABLE 2.
Pooled Efficacy and Safety Outcomes Comparing Effect of Methylene Blue With Placebo or Usual Care
| Outcome | Studies (Patients) | Pooled Risk Ratio or Mean Difference (95% CI) | p | I2 (%) | Grading of Recommendations Assessment, Development, and Evaluation Certainty |
|---|---|---|---|---|---|
| Short-term mortality | 5 (260) | 0.66 (0.47 to 0.95) | 0.02 | 0 | Low |
| Mean arterial pressure at 6 hr (mm Hg) | 3 (82) | 10.2 (6.1 to 14.2) | < 0.00001 | 0 | Low |
| Duration of vasopressors (hr) | 2 (111) | –31.1 (–45.6 to –16.5) | < 0.00001 | 0 | Low |
| ICU length of stay (d) | 3 (133) | –1.1 (–2.6 to 0.5) | 0.19 | 37 | Very low |
| Hospital length of stay (d) | 3 (177) | –2.1 (–2.8 to –1.4) | < 0.0001 | 0 | Low |
| Duration of invasive mechanical ventilation (d) | 3 (141) | –0.7 (–1.3 to –0.2) | 0.01 | 0 | Low |
| Methemoglobin concentration (%) | 3 (133) | 0.9 (–0.2 to 2.0) | 0.11 | 99 | Very low |