Figure 1. Longitudinal vaginal sampling of women with a term or preterm delivery.

(A) Representative diagram showing the collection of vaginal swabs throughout gestation from women who underwent uncomplicated term birth (control; N = 494 subjects, n = 1907 swabs), spontaneous preterm labor with intact membranes (sPTL; N = 140, n = 521), or preterm prelabor rupture of membranes (PPROM; N = 105, n = 391) to quantify the concentrations of cytokines, chemokines, and other immune mediators in the cervico-vaginal fluid by immunoassay. (B) Plots showing the distribution of swabs collected throughout gestation (weeks) for each study group. Gray dots represent gestational ages when vaginal swabs were taken, and green triangles show the gestational age at delivery. (C) Violin plots showing sample frequency across gestational age (weeks) for each study group.

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