TABLE 1.
Comparative analysis of clinical data for training, test, and validation sets.
| Characteristics | PPMI | NACC | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Training set (n = 129) | Test set (n = 54) | Validation set (n = 39) | |||||||
| Nonprogression (n = 94) | Progression (n = 35) | p‐Value | Nonprogression (n = 39) | Progression (n = 15) | p‐Value | Nonprogression (n = 21) | Progression (n = 18) | p‐Value | |
| Sex (n, %) | |||||||||
| Male | 55 (58.5%) | 24 (68.6%) | 0.401 | 28 (71.8%) | 11 (73.3%) | 1.000 | 10 (47.6%) | 12 (66.7%) | 0.232 |
| Female | 39 (41.5%) | 11 (31.4%) | 11 (28.2%) | 4 (26.7%) | 11 (52.4%) | 6 (33.3%) | |||
| Age (year), mean (SD) | 62.6 ± 7.1 | 65.5 ± 7.0 | 0.039* | 64.2 ± 7.2 | 66.3 ± 10.0 | 0.372 | 68.5 ± 6.0 | 72.4 ± 8.3 | 0.083 |
| MoCA, median (IQR) | 28.0 (27.0, 29.0) | 27.0 (26.0, 28.0) | 0.003** | 28.0 (27.0, 29.0) | 27.0 (26.0, 28.0) | 0.108 | 29.0 (27.0, 30.0) | 27.0 (24.5, 29.0) | 0.069 |
| GDS, median (IQR) | 1.0 (0.0,2.0) | 2.0 (1.0,3.0) | 0.065 | 1.0 (0.0,2.0) | 2.0 (1.0,3.0) | 0.021* | 2.0 (1.0,3.0) | 2.0 (1.0,4.0) | 0.568 |
| Educyrs, median (IQR) | 16.0 (14.0, 18.0) | 16.0 (14.0, 18.0) | 0.946 | 16.0 (15.0, 18.0) | 16.0 (14.0, 18.0) | 0.393 | 18.0 (16.0, 18.0) | 18.0 (15.5, 18.5) | 0.568 |
| Symptom1 (n, %) | |||||||||
| No | 23 (24.5%) | 3 (8.6%) | 0.079 | 9 (23.1%) | 1 (6.7%) | 0.318 | 20 (95.2%) | 16 (88.9%) | 0.458 |
| Yes | 71 (75.5%) | 32 (91.4%) | 30 (76.9%) | 14 (93.3%) | 1 (4.8%) | 2 (11.1%) | |||
| Symptom2 (n, %) | |||||||||
| No | 26 (27.7%) | 9 (25.7%) | 1.000 | 8 (20.5%) | 3 (20%) | 1.000 | NA a | NA a | NA |
| Yes | 68 (72.3%) | 26 (74.3%) | 31 (79.5%) | 12 (80%) | |||||
| Symptom3 (n, %) | |||||||||
| No | 9 (9.6%) | 5 (14.3%) | 0.655 | 10 (25.6%) | 4 (26.7%) | 1.000 | 12 (57.1%) | 8 (44.4%) | 0.429 |
| Yes | 85 (90.4%) | 30 (85.7%) | 29 (74.4%) | 11 (73.3%) | 9 (42.9%) | 10 (55.6%) | |||
| Symptom4 (n, %) | |||||||||
| No | 83 (88.3%) | 31 (88.6%) | 1.000 | 37 (94.9%) | 13 (86.7%) | 0.652 | 19 (90.5%) | 12 (66.7%) | 0.066 |
| Yes | 11 (11.7%) | 4 (11.4%) | 2 (5.1%) | 2 (13.3%) | 2 (9.5%) | 6 (33.3%) | |||
| Symptom5 (n, %) | |||||||||
| No | 75 (79.8%) | 31 (88.6%) | 0.368 | 31 (79.5%) | 13 (86.7%) | 0.828 | NA a | NA a | NA |
| Yes | 19 (20.2%) | 4 (11.4%) | 8 (20.5%) | 2 (13.3%) | |||||
| Hy (n, %) | |||||||||
| No | 45 (47.9%) | 14 (40%) | 0.549 | 22 (56.4%) | 6 (40.0%) | 0.437 | NA a | NA a | NA |
| Yes | 49 (52.1%) | 21 (60.0%) | 17 (43.6%) | 9 (60%) | |||||
| ESS (n, %) | |||||||||
| No | 77 (81.9%) | 32 (91.4%) | 0.292 | 30 (76.9%) | 13 (86.7%) | 0.675 | NA a | NA a | NA |
| Yes | 17 (18.1%) | 3 (8.6%) | 9 (23.1%) | 2 (13.3%) | |||||
| RBD (n, %) | |||||||||
| No | 62 (66.0%) | 20 (57.1%) | 0.472 | 30 (76.9%) | 8 (53.3%) | 0.171 | 12 (57.1%) | 11 (61.1%) | 0.802 |
| Yes | 32 (34.0%) | 15 (42.9%) | 9 (23.1%) | 7 (46.7%) | 9 (42.9%) | 7 (38.9%) | |||
Abbreviations: Age (year), Age at Enrollment; Educyrs, Years of Education; Symptom1, Initial symptom (at diagnosis)‐Resting Tremor; ESS, Epworth Sleepiness Scale Score; GDS, Geriatric Depression Scale Score; Hy, Hoehn & Yahr (OFF State); MoCA, Montreal Cognitive Assessment score (adjusted for education); NA, not available; RBD, Rapid Eye Movement Sleep Behavior Disorder Score; Symptom2, Initial symptom (at diagnosis)‐Rigidity; Symptom3, Initial symptom (at diagnosis)‐Bradykinesia; Symptom4, Initial symptom (at diagnosis)‐Postural Instability; Symptom5, Initial symptom (at diagnosis)‐Other.
a
Not available for all NACC study participants.
*
p < 0.05.
**
p < 0.01.