Table 1.

Developmental status of PET tracers for imaging neuroinflammation

Biomarker	Tracer	Developmental status				references
		Radiochemical	Pre-clinical		Clinical
			Rodent	Non-human primate
TSPO	[11C]PK11195	√	√	√	√	[103–106]
	[11C]DAA1106	√	√	√	√	[17, 107–109]
	[11C]DPA713	√	√	√	√	[110–113]
	[18F]PBR06	√	√	√	√	[114–116]
	[11C]PBR28	√	√	√	√	[117–120]
	[18F]DPA714	√	√	√	√	[111, 121, 122]
	[18F]GE180	√	√	-	√	[120, 123, 124]
	[11C]ER176	√	√	√	√	[33, 125–127]
	[18F]BS224	√	√	-	-	[35]
Adenosine	[11C]TMSX	√	√	√	√	[128, 129]
	[11C]SCH442416	√	√	√	√	[130–132]
	[11C]MPDX	√	√	√	√	[133, 134]
	[18F]CPFPX	√	√	√	√	[133, 135–137]
	[11C]Preladenant	√	√	√	√	[138–140]
	[18F]MNI-444	√	-	√	√	[46, 141, 142]
CB2	[11C]Methoxy-Sch225336	√	-	-	-	[51]
	[11C]NE40	√	√	√	√	[53, 143]
	[11C]A-836339	√	√	-	-	[54]
	[11C]GW405833	√	√	-	-	[58]
	[18F]MA3	√	√	√	-	[59, 60]
COX	[11C]KTP-Me	√	√	-	√	[63, 144, 145]
	[11C]PS13	√	-	√	√	[146, 147]
	[11C]MC1	√	-	√	-	[65, 148]
P2X7	[11C]JNJ-54173717	√	√	√	√	[68, 69]
	[18F]JNJ-64413739	√	√	√	√	[70, 71, 149]
CSF-1	[11C]AZ683	√	√	√	-	[73]
	[11C]CPPC	√	√	√	√	[74, 150]
I2BS	[11C]FTIMD	√	√	√	-	[76, 77]
	[11C]metrazoline	√	-	-	-	[80]
	[11C]TEIMD	√	-	-	-	[80]
	[11C]BU99008	√	√	√	√	[151–154]
	[18F]FEBU	√	√	-	-	[79]
MAO-B	[11C]L-deprenyl	√	-	-	√	[87, 155]
	[11C]DED	√	√	-	√	[88, 156, 157]
	[11C]SL25.1188	√	-	√	√	[89, 158, 159]
	[18F]DED	√	√	√	√	[93, 160]
	[18F]FSL25.1188	√	-	√	-	[94]
	[18F]SMBT-1	√	-	-	√	[95, 161]