Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jun 24;15:5339. doi: 10.1038/s41467-024-49676-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 6 — a 3D reconstruction of Fab4251-SOSIP complex by nsEM. b 3D reconstruction of Fab2101-SOSIP complex by nsEM. c Side and top views of the cryo-EM density map of the Fab4251-DS-SOSIP complex, with gp120 in light gray, gp41 in dark gray, VH in violet, and VL in pink. d Atomic model of Fab4251-DS-SOSIP complex shown in cartoon representation. e Footprint representation of the heavy and light-chain binding surface on DS-SOSIP, colored according to (c). Inlet on the right represents the CDRH2 loop in violet, with H54 in the F43 cavity. f Overlay of CD4 receptor (green) bound to SOSIP (PDB.5U1F) and Fab4251 (violet). g Close view of VH H54 from Fab4251 and F43 in CD4. h Overlay of VRC01-class antibodies on SOSIP with Fab4251 (violet), VRC01 (PDB.6V8X, green), PG04 (PDB.4I3S, red), and 3BNC60 (PDB.4GW4, orange).