Table 1.
Laboratory parameters over time.
| Lab value | Reference value | Admission | PEA arrest day | HLH-2004 D1 | HLH-2004 D4 | HLH 2004 D8 | Pre- Toci dose 1 | Pre- Toci dose 2 | Post- Toci | Discharge |
|---|---|---|---|---|---|---|---|---|---|---|
| Day 0 | Day 10 | Day 13 | Day 16 | Day 20 | Day 27 | Day 28 | Day 30 | Day 48 | ||
| Ferritin | 4–205 µg/L | 128,619 | 20267 | 4573 | 3213 | 3627 | 3949 | 3237 | ||
| LDH | 120–315 U/L | 5210 | 559 | 414 | 188 | 359 | ||||
| CRP | 0–1 mg/L | 317.1 | 312.6 | 98.4 | 28.0 | 242.6 | 267.6 | 28.3 | 0.4 | |
| AST | 10–35 U/L | 1186 | 64 | 84 | 13 | 8 | 15 | 33 | ||
| ALT | 8–40 U/L | 31 | 29 | 615 | 124 | 131 | 50 | 37 | 40 | 127 |
| Cr | 0–85 umol/L | 91 | 379 | 531 | 211 | 163 | 123 | 128 | 122 | 111 |
| WBC | 4.0–11.0 x10 9/L | 1.18 | 6.33 | 17.5 | 23.0 | 5.8 | 0.5 | 0.7 | 6.2 | 16.0 |
| Neut | 2.0–7.50 x 10 9/L | 0.11 | 2.91 | 14.13 | 22.36 | 4.78 | 0.02 | 0.05 | 3.00 | 13.87 |
| Hb | 115–155 g/L | 86 | 79 | 64 | 78 | 78 | 87 | 84 | 87 | 85 |
| Plt | 150–450 x10 9/L | 83 | 101 | 50 | 66 | 64 | 11 | 15 | 34 | 119 |
If the lab value of interest was not available for a specified timepoint but a value within 1–2 days was available, this is provided in place.
PEA, pulseless electrical activity; LDH, lactate dehydrogenase; CRP, C-reactive protein; AST, aspartate transaminase; ALT, alanaine transaminase; Cr, creatinine; WBC, white blood cells; Neut, neutrophils; Hb, hemaglobin; Plt, platelets; Toci, tocilizumab.