Table 2.
rs9838094 and rs1818033 polymorphism association analysis with gender incongruence in trans and cis populations, in different models of inheritance.
| rs9838094 association with GI (n=187, adjusted by sex) | |||||||
|---|---|---|---|---|---|---|---|
| Model | Genotypes | Cis group Count/Proportion |
Trans group Count/Proportion |
OR (95% CI) | P-value | AIC | BIC |
| Codominant | G/G | 54 (57.5%) | 73 (78.5%) | Reference 1.00 | 5.00E-04*† | 252.1 | 265 |
| T/G | 34 (36.2%) | 20 (21.5%) | 0.43 (0.23–0.84) |
||||
| T/T | 6 (6.4%) | 0 (0%) | 0.00 (0.00-NA) |
||||
| Dominant | G/G | 54 (57.5%) | 73 (78.5%) | Reference 1.00 | 0.0018* | 255.4 | 265.1 |
| T/G-T/T | 40 (42.5%) | 20 (21.5%) | 0.37 (0.19–0.70) |
||||
| Recessive | G/G-T/G | 88 (93.6%) | 93 (100%) | Reference 1.00 | 0.0033* | 256.5 | 266.2 |
| T/T | 6 (6.4%) | 0 (0%) | 0.00 (0.00-NA) |
||||
| Overdominant | G/G-T/T | 60 (63.8%) | 73 (78.5%) | Reference 1.00 | 0.026* | 260.2 | 269.9 |
| T/G | 34 (36.2%) | 20 (21.5%) | 0.48 (0.25–0.93) |
||||
| Log-additive | — | — | — | 0.36 (0.20–0.65) |
4.00E-04*† | 252.5 | 262.2 |
| rs1818033 association with GI (n=188, adjusted by sex) | |||||||
| Codominant | C/C | 34 (36.2%) | 55 (58.5%) | Reference 1.00 | 6.00E-04*† | 253.5 | 266.4 |
| C/G | 45 (47.9%) | 36 (38.3%) | 0.50 (0.27–0.92) |
||||
| G/G | 15 (16%) | 3 (3.2%) | 0.12 (0.03–0.45) |
||||
| Dominant | C/C | 34 (36.2%) | 55 (58.5%) | Reference 1.00 | 0.002* | 256.9 | 266.6 |
| C/G-G/G | 60 (63.8%) | 39 (41.5%) | 0.40 (0.22–0.72) |
||||
| Recessive | C/C-C/G | 79 (84%) | 91 (96.8%) | Reference 1.00 | 0.0017* | 256.5 | 266.3 |
| G/G | 15 (16%) | 3 (3.2%) | 0.17 (0.05–0.60) |
||||
| Overdominant | C/C-G/G | 49 (52.1%) | 58 (61.7%) | Reference 1.00 | 0.19 | 264.7 | 274.4 |
| C/G | 45 (47.9%) | 36 (38.3%) | 0.68 (0.38–1.21) |
||||
| Log-additive | — | — | — | 0.42 (0.26–0.67) |
2.00E-04*† | 252.3 | 262 |
* Reached statistical significance.
† Passed the Bonferroni correction.