Table 5.

Haplotype and Haplotype interaction analyses with the covariate natal sex. The table shows the haplotype frequencies estimation and the haplotype association with GI.

Haplotype analysis
Haplotype frequencies estimation (n=188)
Haplotypes	rs9838094	rs1818033	Total	Cis group	Trans group	Cumulative frequency
1	G	C	0.6888	0.6011	0.7766	0.6888
2	T	G	0.1786	0.2447	0.1117	0.8674
3	G	G	0.1326	0.1543	0.1117	1
4	T	C	0	0	0	1
Haplotype association with response (n=188, adjusted by sex)
	rs9838094	rs1818033	Freq	OR (95% CI)		P-value
1	G	C	0.6888	Reference 1.00		—
2	T	G	0.1781	0.34 (0.19 - 0.62)		6.00E-04*†
3	G	G	0.133	0.54 (0.28 - 1.04)		0.065
Global haplotype association p-value: 0.00046*†
Haplotype interaction analysis with covariate natal sex
Haplotype and sex cross-classification interaction table (n=188, crude analysis)
Haplotype	Frequency	Females	P-value	Males		P-value
		OR (95% CI)		OR (95% CI)
GC	0.6888	Reference 1.00	–	1.13 (0.49 - 2.58)		0.785
GG	0.1332	0.47 (0.19 - 1.19)	0.106	0.70 (0.26 - 1.90)		0.491
TG	0.178	0.34 (0.14 - 0.82)	0.016*	0.38 (0.15 - 0.95)		0.039*
Interaction p-value: 0.91
Haplotypes within sex (n=188, crude analysis)
GC	0.6888	Reference 1.00	–	Reference 1.00		–
GG	0.1332	0.47 (0.19 - 1.19)	0.106	0.62 (0.25 - 1.57)		0.312
TG	0.178	0.34 (0.14 - 0.82)	0.016*	0.34 (0.15 - 0.77)		0.009*
Sex within haplotypes (n=188, crude analysis)
		OR (95% CI)		OR (95% CI)
GC	0.6888	Reference 1.00	–	1.13 (0.49 - 2.58)		0.785
GG	0.1332	Reference 1.00	–	1.49 (0.48 - 4.62)		0.499
TG	0.178	Reference 1.00	–	1.11 (0.40 - 3.10)		0.852

* Reached statistical significance.

† Passed the Bonferroni correction.