Figure 1.

A novel mouse model to study the effects of partial hepatectomy in orthotopic metastasized colorectal carcinoma. (A) Overview of experimental layout (top) and timeline for procedures (bottom); (B) Representative images of primary tumor ex vivo (scale bar = 0.5 cm) and T2-weighted transversal MRI of early primary tumor (red circle) and locally advanced primary tumor in ultrasound; (C) Representative HE-staining of liver with premetastatic lesion (red square) and of advanced liver metastasis (LM) (scale bars in left panels = 200 µm and in right panels =100 µm); (D) Representative images of liver and LM ex vivo (scale bar = 0.5 cm) and of T2-hyperintense LM (red circle) in the medial hepatic lobe (max. diameter 7 mm) in transversal T2-weighted MRI and in ultrasound of the same liver metastasis (red circle).