Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2024 Jun 10;15:1388272. doi: 10.3389/fimmu.2024.1388272

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2024 Luenstedt, Hoping, Feuerstein, Mauerer, Berlin, Rapp, Marx, Reichardt, von Elverfeldt, Ruess, Plundrich, Laessle, Jud, Neeff, Holzner, Fichtner-Feigl and Kesselring

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Partial hepatectomy induces premetastatic niche (PMN) formation in the liver. (A) Relative mRNA levels (normalized on preoperative values) of the PMN-associated genes S100a9, Il6, Fn1, Hif1a, Lox, Vegfa, Tgfb1, Timp1, Mmp2 and Mmp9 in healthy liver tissue analyzed by qPCR for PO (n=26), Ctrl (n=4), SHAM (n=17) and pHx (n=26) groups; (B, C) Western Blot analyses of the expression of the premetastatic niche factors S100A8 and MMP9 from healthy liver (top). β-actin was used as loading control; (D, E) Representative IHC stainings of liver sections (bottom) of S100A8 and MMP9, red square marking perivascular premetastatic lesions (scale bars = 100 µm). (Bar plots represent mean ± SEM, p-values calculated via one-way ANOVA Tukey test, * = p<0.05, n.s. non significant.