Table 5.
Laboratory results* at initial diagnosis, first presumed relapse and during cyclophosphamide therapy in cats with relapsed low-grade alimentary lymphoma receiving rescue cyclophosphamide after failing chlorambucil treatment
| Hematology | At initial diagnosis, n (n = 16 total † ) | At first presumed relapse, n (n = 16 total ‡ ) | During cyclophosphamide therapy, n (n = 15 total § ) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Grade 1 or 2 | Grade 3 or 4 | Total | Grade 1 or 2 | Grade 3 or 4 | Total | Grade 1 or 2 | Grade 3 or 4 | Total | |
| Anemia | 3 | 0 | 3 | 5 | 0 | 5 | 8 | 0 | 8 |
| Neutropenia | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 4 |
| Thrombocytopenia | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Biochemistry ¶ | At initial diagnosis, n (n = 11 total † ) | At first presumed relapse, n (n = 10 total ‡ ) | During cyclophosphamide therapy, n (n = 12 total § ) | ||||||
| Grade 1 or 2 | Grade 3 or 4 | Total | Grade 1 or 2 | Grade 3 or 4 | Total | Grade 1 or 2 | Grade 3 or 4 | Total | |
| Increased BUN | 3 | 0 | 3 | 2 | 0 | 2 | 4 | 0 | 4 |
| Increased creatinine | 3 | 0 | 3 | 1 | 0 | 1 | 1 | 0 | 1 |
| Increased ALT | 2 | 0 | 2 | 0 | 1 | 1 | 0 | 0 | 0 |
| Increased ALP | 1 | 1 | 2 | 0 | 1 | 1 | 0 | 0 | 0 |
| Increased potassium | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
| Increased bilirubin | 1 | 1 | 2 | 1 | 0 | 1 | 0 | 0 | 0 |
| Increased glucose | 1 | 0 | 1 | 2 | 0 | 2 | 1 | 0 | 1 |
| Increased T4 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 |
| Decreased potassium | 0 | 0 | 0 | 2 | 0 | 2 | 1 | 0 | 1 |
| Decreased calcium | 0 | 0 | 0 | 1 | 0 | 1 | 2 | 0 | 2 |
| Decreased albumin | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 |
Seven cats had a urinalysis performed only at initial diagnosis; aside from trace to 1 + proteinuria in four cats, all results were unremarkable
Laboratory results were collected at the time of initial diagnosis
Laboratory results were collected at the time of first presumed relapse (ie, start of cyclophosphamide treatment)
Laboratory results were collected at various time points throughout cyclophosphamide therapy at the discretion of the specific overseeing clinician
Four cats were reported to have any combination of increased serum folate, trypsin-like immunoreactivity, pancreatic lipase immunoreactivity and/or decreased serum cobalamin that were subjectively mild-to-moderate in severity (no grading system exists for these parameters) and were only evaluated at initial diagnosis. The cats with decreased serum cobalamin received cobalamin supplementation
BUN = blood urea nitrogen; ALT = alanine transaminase; ALP = alkaline phosphatase; T4 = thyroxine