Table 5.
Cox regression univariate and multivariate associations of clinicopathologic characteristics with overall survival
| Overall survival | ||||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||
| Variable | HR | 95% CI | P value | aHR | 95% CI | P value |
| Sex | ||||||
| Male | 1 | (ref) | ||||
| Female | 0.88 | 0.482–1.606 | 0.677 | |||
| Age | ||||||
| < mean | 1 | (ref) | 1 | (ref) | ||
| > mean | 2.456 | 1.455–4.144 | < 0.001* | 2.314 | 1.094–4.898 | 0.028* |
| Smoking habit | ||||||
| Nonsmoker | 1 | (ref) | ||||
| Smoker | 1.855 | 0.998–3.447 | 0.051 | |||
| Localization | ||||||
| Tonsil | 1 | (ref) | ||||
| Base of tongue | 1.367 | 0.74–2.526 | 0.318 | |||
| Other | 4.071 | 1.943–8.531 | < 0.001* | |||
| Differentiation grade | ||||||
| Low | 1 | (ref) | ||||
| Moderate | 2.485 | 1.365–4.525 | 0.003* | |||
| High | 1.785 | 0.642–4.962 | 0.266 | |||
| Stage TNM 8 | ||||||
| I-II | 1 | (ref) | 1 | (ref) | ||
| III-IV | 4.217 | 2.47–7.199 | < 0.001* | 2.915 | 1.221–6.961 | 0.016* |
| HPV status | ||||||
| HPV-driven | 1 | (ref) | 1 | (ref) | ||
| Not HPV-driven | 3.463 | 2.083–5.759 | < 0.001* | 1.771 | 0.777–4.036 | 0.174 |
| LMO7 expression | ||||||
| Low (0–50%) | 1 | (ref) | 1 | (ref) | ||
| High (51–100%) | 0.515 | 0.267–0.994 | 0.048* | 0.586 | 0.297–1.153 | 0.122 |
| LRIG1 staining intensity | ||||||
| No/weak/intermediate | 1 | (ref) | ||||
| Strong | 1.644 | 0.777–3.478 | 0.194 | |||
| CD44 staining intensity | ||||||
| No/weak/intermediate | 1 | (ref) | ||||
| Strong | 2.272 | 1.144–4.515 | 0.019* | |||
| Ki67 expression | ||||||
| mean | 1 | (ref) | 1 | (ref) | ||
| mean | 0.446 | 0.217–0.918 | 0.028* | 0.418 | 0.193–0.906 | 0.027* |
| p53 expression | ||||||
| Wild-type | 1 | (ref) | ||||
| Mutated | 4.476 | 2.358–8.497 | < 0.001* | |||
HPV human papilloma virus, LMO7 LIM domain 7 protein, LRIG leucine-rich repeats and immunoglobulin-like domain
* = P < 0.05