Table 6.
Cox regression univariate and multivariate associations of clinicopathologic characteristics with disease-free survival
| Disease-free survival | ||||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||
| Variable | HR | 95% CI | P value | aHR | 95% CI | P value |
| Sex | ||||||
| Male | 1 | (ref) | ||||
| Female | 0.915 | 0.398–2.102 | 0.834 | |||
| Age | ||||||
| < mean | 1 | (ref) | ||||
| > mean | 1.147 | 0.581–2.261 | 0.693 | |||
| Smoking habit | ||||||
| Nonsmoker | 1 | (ref) | ||||
| Smoker | 2.275 | 0.984–5.261 | 0.055 | |||
| Localization | ||||||
| Tonsil | 1 | (ref) | ||||
| Base of tongue | 1.175 | 0.506–2.728 | 0.707 | |||
| Other | 2.324 | 0.699–7.725 | 0.169 | |||
| Differentiation grade | ||||||
| Low | 1 | (ref) | ||||
| Moderate | 2.121 | 0.998–4.508 | 0.051 | |||
| High | 1.356 | 0.297–6.197 | 0.694 | |||
| Stage TNM 8 | ||||||
| I-II | 1 | (ref) | 1 | (ref) | ||
| III-IV | 3.525 | 1.78–6.983 | < 0.001* | 1.717 | 0.595–4.958 | 0.317 |
| HPV status | ||||||
| HPV-driven | 1 | (ref) | 1 | (ref) | ||
| Not HPV-driven | 4.529 | 2.295–8.94 | < 0.001* | 1.806 | 0.428–7.615 | 0.421 |
| LMO7 expression | ||||||
| Low (0–50%) | 1 | (ref) | ||||
| High (51–100%) | 0.468 | 0.187–1.175 | 0.106 | |||
| LRIG1 staining intensity | ||||||
| No/weak/intermediate | 1 | (ref) | ||||
| Strong | 1.139 | 0.336–3.87 | 0.834 | |||
| CD44 staining intensity | ||||||
| no/weak/intermediate | 1 | (ref) | 1 | (ref) | ||
| strong | 3.126 | 1.243–7.858 | < 0.015* | 1.596 | 0.591–4.308 | 0.356 |
| Ki67 expression | ||||||
| mean | 1 | (ref) | ||||
| mean | 0.642 | 0.259–1.591 | 0.338 | |||
| p53 expression | ||||||
| Wild-type | 1 | (ref) | 1 | (ref) | ||
| Mutated | 5.118 | 2.109–12.424 | < 0.001* | 2.849 | 0.757–10.727 | 0.122 |
HPV human papillomavirus, LMO7 LIM domain 7 protein, LRIG leucine-rich repeats and immunoglobulin-like domain
* = P < 0.05