Table 7.
Cox regression univariate and multivariate associations of overall survival with clinicopathologic characteristics, in HPV-driven tumors
| HPV-driven tumors, overall survival | ||||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||
| Variable | HR | 95% CI | P-value | aHR | 95% CI | P-value |
| Sex | ||||||
| Male | 1 | (ref) | ||||
| Female | 0.816 | 0.337–1.975 | 0.652 | |||
| Age | ||||||
| < mean | 1 | (ref) | 1 | (ref) | ||
| > mean | 2.958 | 1.459–5.999 | 0.003* | 2.93 | 1.072–8.005 | 0.036* |
| Smoking habit | ||||||
| Nonsmoker | 1 | (ref) | ||||
| Smoker | 1.343 | 0.634–2.842 | 0.441 | |||
| Localization | ||||||
| Tonsil | 1 | (ref) | ||||
| Base of tongue | 0.347 | 0.083–1.455 | 0.148 | |||
| Other | 2.853 | 0.862–9.444 | 0.086 | |||
| Differentiation grade | ||||||
| Low | 1 | (ref) | ||||
| Moderate | 1.775 | 0.843–3.738 | 0.131 | |||
| High | 0.571 | 0.073–4.475 | 0.594 | |||
| Stage TNM 8 | ||||||
| I-II | 1 | (ref) | 1 | (ref) | ||
| III-IV | 3.123 | 1.569–6.217 | 0.001* | 3.871 | 1.474–10.167 | 0.006* |
| LMO7 expression | ||||||
| Low (0–50%) | 1 | (ref) | ||||
| High (51–100%) | 0.438 | 0.166–1.160 | 0.097 | |||
| LRIG1 staining intensity | ||||||
| No/weak/intermediate | 1 | (ref) | 1 | (ref) | ||
| Strong | 3.114 | 1.178–8.232 | 0.022* | 2.847 | 1.036–7.825 | 0.043* |
| CD44 staining intensity | ||||||
| no/weak/intermediate | 1 | (ref) | ||||
| strong | 3.22 | 1.132–9.154 | 0.028* | |||
| Ki67 expression | ||||||
| mean | 1 | (ref) | ||||
| mean | 0.605 | 0.229–1.6 | 0.311 | |||
HPV human papilloma virus, LRIG leucine-rich repeats and immunoglobulin-like domain, LMO7 LIM domain 7 protein
* = P < 0.05