Table 3.
Gene information for primary human astrocyte positive rhAbs
| rhAb name | rhAb category | VH gene JH gene |
CDR3 AA length |
CDR3 charge |
VH #RM |
VL gene JL gene |
VL #RM |
Patient |
|---|---|---|---|---|---|---|---|---|
| PTM-2 | VH3 + SHM− |
VH3-7 JH6 |
25 | 0 | 0 |
VK1-39 JK5 |
0 | PTM-A |
| PTM-4 | VH3 + SHM+ |
VH3-7 JH4 |
10 | 0 | 11 |
VK2-30 JK4 |
2 | PTM-A |
| PTM-6 | VH3 + SHM+ |
VH3-30 JH4 |
20 | 1 | 9 |
VK1-27 JK5 |
4 | PTM-B |
| PTM-9 | VH4 + SHM− |
VH4-39 JH4 |
19 | 1 | 0 |
VK3-20 JK2 |
0 | PTM-B |
| PTM-12 | VH4 + SHM+ |
VH4-4 JH4 |
14 | − 3 | 5 |
VK3-11 JK2 |
9 | PTM-C |
VH variable heavy, JH junction heavy, CDR3 complementarity determining region 3, AA amino acid, #RM number of replacement mutations, VL variable light