Table 2.
Basic statistics of liver function biomarkers and correlation matrix (N = 356,894)
| Liver function biomarkers, mean ± SD | Overall (N = 356,894) |
Without incident liver cancer (N = 356,500) |
Incident liver cancer (N = 394) |
P valuea | Spearman correlation coefficientb | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALT | AST | TBIL | GGT | ALP | TP | ALB | |||||
| ALT (U/L) | 23.64 ± 14.13 | 23.62 ± 14.08 | 40.56 ± 32.68 | < 0.001 | 1 | 0.70 | 0.12 | 0.60 | 0.18 | 0.13 | 0.14 |
| AST (U/L) | 26.19 ± 10.04 | 26.17 ± 9.98 | 43.88 ± 31.08 | < 0.001 | - | 1 | 0.16 | 0.43 | 0.15 | 0.18 | 0.15 |
| TBIL (μmol//L) | 9.19 ± 4.43 | 9.19 ± 4.43 | 11.16 ± 6.50 | < 0.001 | - | - | 1 | 0.10 | − 0.11 | 0.08 | 0.21 |
| GGT (U/L) | 37.40 ± 41.06 | 37.29 ± 40.50 | 136.62 ± 182.25 | < 0.001 | - | - | - | 1 | 0.23 | 0.15 | 0.11 |
| ALP (U/L) | 82.89 ± 25.10 | 82.87 ± 24.97 | 106.67 ± 76.01 | < 0.001 | - | - | - | - | 1 | 0.11 | − 0.03 |
| TP (g/L) | 72.54 ± 4.08 | 72.54 ± 4.08 | 73.40 ± 4.80 | < 0.001 | - | - | - | - | - | 1 | 0.48 |
| ALB (g/L) | 45.26 ± 2.61 | 45.26 ± 2.61 | 44.12 ± 3.12 | < 0.001 | - | - | - | - | - | - | 1 |
Abbreviations: ALT alanine transaminase, AST aspartate transaminase, TBIL total bilirubin, GGT gamma-glutamyl transferase, ALP alkaline phosphatase, TP total protein, ALB albumin
aT-test test was used to compare the differences in liver function biomarkers between participants without incident liver cancer and participants with incident liver cancer
bAll P < 0.001