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The functions of CNS fibroblasts in health and disease.
| Health | Disease |
|---|---|
| • Structural support/ECM • Molecular cues for cell (immune cells and neurons) migration and positioning • Regulation of neurogenesis • Providing trophic factors |
• Fibrotic scar/fibrosis in spinal cord injury, traumatic brain injury, experimental autoimmune encephalomyelitis, and stroke • Neuroinflammation • Tertiary lymphoid organ formation |
