Figure 2.

Change in gut microbiome composition after RS2 and RS4 treatments varies between individuals.

(a) This heat map shows the change in mean relative abundance of ASVs across all participants by treatment (RS2, RS4, and control) for taxa that significantly differed in abundance from Pre to End of the RS2 and RS4 treatments in our MaAsLin2 models (q < 0.05). Descriptions above the taxa names on the left indicate whether the ASVs were significant for both RS2 and RS4, RS2 only, or RS4 only. Although the mean log₂ fold change in relative abundance of taxa during the control treatment is shown, no ASVs significantly changed in response to the control treatment at q < 0.05. For each cell, colors indicate the log₂ fold change in relative abundance of taxa between Pre and End treatment time points. Repeated taxa indicate the same taxonomic assignment to different ASVs. Data from all participants was included regardless of order of treatment. (b) These are the same differentially abundant ASVs in panel (a), but shown here are the log₂ fold changes of the relative abundances of the ASVs for individual participants during RS2 (top) and RS4 (bottom) (RS2: n = 57, RS4: n = 55, control: n = 55).