Table 3.
Three-Year Incidence of Dementia Subtype Diagnoses Among Patients With Systolic HF (ICD-10-CM: I50.2 or I50.4) Receiving Sacubitril/Valsartan vs Propensity Score-Matched Patients Receiving ACEIs or ARBs
| Sacubitril/Valsartan (n = 13,323)a |
ACEI/ARB (n = 13,323)a |
HR (95% CI) | P Value | |||
|---|---|---|---|---|---|---|
| Events | 3-y K-M Estimate | Events | 3-y K-M Estimate | |||
| Vascular dementia | 80 | 0.96% | 132 | 1.54% | 0.61 (0.46-0.81) | 0.001 |
| Dementia in other diseases | 81 | 0.96% | 149 | 1.74% | 0.55 (0.42-0.72) | <0.001 |
| Unspecified dementia | 233 | 2.83% | 358 | 4.18% | 0.65 (0.55-0.77) | <0.001 |
ACEI = angiotensin-converting enzyme inhibitor; ARB = angiotensin II receptor blocker; HF = heart failure; ICD-10-CM = International Classification of Diseases-10th Revision-Clinical Modification; K-M = Kaplan-Meier.
a
Patients with prevalent diagnoses of interest at baseline were excluded from calculation of incidence for each analysis. Outcomes were defined using the following ICD-10-CM codes: vascular dementia, F01; dementia in other diseases, F02; and unspecified dementia, F03.