Table 2.
Association of Nontraditional ASCVD Risk Factors (per SD Increase) With Incident CAC
| Risk Factora | All (N = 815) |
Men (n = 270) |
Women (n = 545) |
|||
|---|---|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Lipid | ||||||
| Apo-B, per 10 mg/dL higher | 0.91 (0.65-1.28) | 0.60 | 0.77 (0.36-1.66) | 0.51 | 0.95 (0.64-1.43) | 0.82 |
| Lp(a), per 10 mg/dL higher | 1.00 (0.88-1.14) | 0.99 | 1.17 (0.89-1.54) | 0.26 | 0.94 (0.80-1.09) | 0.41 |
| Myocardial | ||||||
| Hs-cTnT, per 6 ng/mL higher | 1.03 (0.88-1.21) | 0.69 | 1.07 (0.89-1.30) | 0.47 | 1.00 (0.78-1.30) | 0.98 |
| NT-proBNP, per 163 mg/dL higher | 1.10 (0.99-1.22) | 0.08 | 1.22 (1.08-1.39) | 0.002 | 1.10 (0.87-1.17) | 0.91 |
| Renal | ||||||
| eGFR, per 14 mL/min/1.73 m2 lower | 1.19 (1.05-1.34) | 0.005 | 0.87 (0.70-1.08) | 0.21 | 1.36 (1.17-1.58) | <0.001 |
| Urinary albumin-creatinine ratio, per 168 mg/g higher | 1.17 (1.08-1.26) | <0.001 | 1.15 (1.05-1.26) | 0.003 | 1.23 (0.99-1.53) | 0.06 |
| Inflammatory | ||||||
| CRP, per 6 mg/L higher | 1.03 (0.93-1.15) | 0.57 | 0.88 (0.62-1.24) | 0.46 | 1.10 (0.98-1.23) | 0.10 |
Apo-B = apolipoprotein-B; ASCVD = atherosclerotic cardiovascular disease; CAC = coronary artery calcium; CRP = C-reactive protein; eGFR = estimated glomerular filtration rate; hs-cTnT = high-sensitivity cardiac troponin T; Lp(a) = lipoprotein a; NT-proBNP = N-terminal pro-brain natriuretic peptide.
a
Each nontraditional risk factor was evaluated independently after adjustment for age, systolic blood pressure, diastolic blood pressure, total cholesterol, HDL-cholesterol, fasting blood glucose, fasting serum triglycerides, waist circumference, cigarette smoking, antihypertensive medication, lipid-lowering medication, and glucose-lowering medication